EWAS

From ReactomeWiki

An EntityWithAccessionedSequence ia a full-length protein, RNA, or DNA or fragments of them. It must be linked to a protein or polynucleotide sequence in an external database entered as the value of referenceSequence. By default, an EntityWithAccessionedSequence corresponds to the entire protein or polynucleotide described in the external database. To annotate a fragment, the numbers of its first and last residues, following the numbering scheme used in the external database, are entered as values of the startCoordinate and endCoordinate slots. A value of 0 indicates an unknown coordinate. Default start and end coordinates for a full-length sequence entity, assigned automatically if no values are provided by the curator, are 1 and -1, respectively. (-1 is a Perl usage which means the last element of an array; here, the last residue). Separate EntityWithAccessionedSequence instances are needed for each subcellular location (compartment) in which a molecule is found, e.g., kallikrein light chain \[extracellular\] and kallikrein light chain \[plasma membrane\].